Inhibition of nucleotide sugar transport in Trypanosoma brucei alters surface glycosylation.

@article{Liu2013InhibitionON,
  title={Inhibition of nucleotide sugar transport in Trypanosoma brucei alters surface glycosylation.},
  author={Li Liu and Yu-xin Xu and Kacey L Caradonna and Emilia K. Kruzel and Barbara A Burleigh and James D Bangs and Carlos B. Hirschberg},
  journal={The Journal of biological chemistry},
  year={2013},
  volume={288 15},
  pages={10599-615}
}
Nucleotide sugar transporters (NSTs) are indispensible for the biosynthesis of glycoproteins by providing the nucleotide sugars needed for glycosylation in the lumen of the Golgi apparatus. Mutations in NST genes cause human and cattle diseases and impaired cell walls of yeast and fungi. Information regarding their function in the protozoan parasite, Trypanosoma brucei, a causative agent of African trypanosomiasis, is unknown. Here, we characterized the substrate specificities of four NSTs… CONTINUE READING
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