Inhibition of nucleolar transcription as a trigger for neuronal apoptosis.

@article{Kalita2008InhibitionON,
  title={Inhibition of nucleolar transcription as a trigger for neuronal apoptosis.},
  author={Katarzyna B Kalita and Denys Y. Makonchuk and Cynthia Gomes and Jing-Juan Zheng and Michal Hetman},
  journal={Journal of neurochemistry},
  year={2008},
  volume={105 6},
  pages={
          2286-99
        }
}
In post-mitotic neurons, the mechanisms of the apoptotic checkpoint that is activated by DNA damage remain unclear. Here we show that in cultured cortical neurons, the DNA damaging agent camptothecin (CPT) reduced transcription of rRNA and disrupted nucleolar staining for B23/nucleophosmin suggesting DNA damage-induced nucleolar stress. Although CPT activated the pro-apoptotic protein p53, the CPT-induced nucleolar stress was unaffected by p53 inhibition. In addition, brain-derived neurotrophic… CONTINUE READING

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