Inhibition of nucleation and crystal growth of calcium carbonate by human lithostathine.

  title={Inhibition of nucleation and crystal growth of calcium carbonate by human lithostathine.},
  author={J. P. Bernard and Zygmunt Adrich and Giulia Montalto and A De caro and Max de Reggi and Henri Sarles and Jean Charles Dagorn},
  volume={103 4},
Pancreatic juice is naturally supersaturated in calcium and bicarbonate ions. A mechanism controlling CaCO3 crystal formation and growth is therefore necessary to prevent duct clogging. The present study shows that lithostathine, a glycoprotein present in human pancreatic juice at a concentration in the range of 10 mumol/L, could be involved in such a control. Lithostathine in concentrations greater than 1.5 mumol/L significantly delayed crystal nucleation and inhibited growth of preformed… CONTINUE READING


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