Inhibition of nuclear factor-kappaB activity is involved in E1A-mediated sensitization of radiation-induced apoptosis.

@article{Shao1997InhibitionON,
  title={Inhibition of nuclear factor-kappaB activity is involved in E1A-mediated sensitization of radiation-induced apoptosis.},
  author={Rhao Shao and Devarajan Karunagaran and Binhua Peter Zhou and Ke Li and Sue S.T. Lo and Jiusheng Deng and Pj Chiao and Mien Chie Hung},
  journal={The Journal of biological chemistry},
  year={1997},
  volume={272 52},
  pages={
          32739-42
        }
}
The adenoviral E1A protein has been implicated in the potentiation of apoptosis induced by various external stimuli, but the exact mechanism of that potentiation is not clear. In this study, we compared the sensitivity to ionizing gamma-irradiation of E1A transfectants with that of parental cells in a human ovarian cancer cell line (SKOV3.ip1); we found that the E1A transfectants became sensitive to radiation-induced apoptosis. Recently, activation of the transcription factor nuclear factor… CONTINUE READING

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