Inhibition of nuclear factor kappaB activation in PC3 cells by genistein is mediated via Akt signaling pathway.

@article{Li2002InhibitionON,
  title={Inhibition of nuclear factor kappaB activation in PC3 cells by genistein is mediated via Akt signaling pathway.},
  author={Yiwei Li and Fazlul H. Sarkar},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2002},
  volume={8 7},
  pages={2369-77}
}
Prostate cancer is the second leading cause of cancer-related deaths in menin the United States. Genistein is a prominent isoflavonoid found in soy products and has been proposed to be responsible for lowering the rate of prostate cancer in Asians. However, the molecular mechanism(s) by which genistein elicits its effects on prostate cancer cells has not been fully elucidated. We have previously shown that genistein induces apoptosis and inhibits the activation of nuclear factor kappaB (NF… CONTINUE READING
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