Inhibition of nuclear accumulation of karyophilic proteins in living cells by microinjection of the lectin wheat germ agglutinin.

@article{Dabauvalle1988InhibitionON,
  title={Inhibition of nuclear accumulation of karyophilic proteins in living cells by microinjection of the lectin wheat germ agglutinin.},
  author={Marie Christine Dabauvalle and Barbara E Schulz and Ulrich Scheer and Reiner Peters},
  journal={Experimental cell research},
  year={1988},
  volume={174 1},
  pages={
          291-6
        }
}
The lectin wheat germ agglutinin (WGA), which has been reported to inhibit nuclear protein uptake in vitro by isolated nuclei (Finlay et al. (1987) J. Cell Biol. 104, 189), also blocks, on microinjection into living cells, the migration of proteins into the cell nucleus. Radioactively labeled nuclear proteins were injected into the cytoplasm of Xenopus oocytes and their reentry into the nucleus was analyzed in the presence or absence of WGA by two-dimensional gel electrophoresis. In another set… CONTINUE READING
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