Inhibition of nuclear DNA synthesis by an autoantibody to proliferating cell nuclear antigen/cyclin.

@article{Wong1987InhibitionON,
  title={Inhibition of nuclear DNA synthesis by an autoantibody to proliferating cell nuclear antigen/cyclin.},
  author={Ruth Yeang Lam Wong and Marion Katz and Kiyoshi Ogata and Eng M Tan and Sharon R Cohen},
  journal={Cellular immunology},
  year={1987},
  volume={110 2},
  pages={
          443-8
        }
}
Proliferating cell nuclear antigen (PCNA) is expressed in the nuclei of proliferating cells, but is not detected in resting cells. The kinetics of PCNA expression suggest that it is associated with a phase preceding active DNA synthesis. DNA synthesis is under cytoplasmic control, and there is a cytoplasmic protein, ADR (activator of DNA replication), that induces DNA synthesis in isolated quiescent nuclei. We now report that a human antibody preparation monospecific for PCNA, but not two… CONTINUE READING
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