Inhibition of norovirus replication by morpholino oligomers targeting the 5'-end of the genome.

@article{Bok2008InhibitionON,
  title={Inhibition of norovirus replication by morpholino oligomers targeting the 5'-end of the genome.},
  author={Karin Bok and Victoria J. Cavanaugh and David O. Matson and Lorenzo Gonz{\'a}lez-Molleda and Kyeong-Ok Chang and Carmelann Zintz and A. W. Sam Smith and Patrick I Iversen and Kim Y Green and Ann E. Campbell},
  journal={Virology},
  year={2008},
  volume={380 2},
  pages={328-37}
}
Noroviruses are an important cause of non-bacterial epidemic gastroenteritis, but no specific antiviral therapies are available. We investigated the inhibitory effect of phosphorodiamidiate morpholino oligomers (PMOs) targeted against norovirus sequences. A panel of peptide-conjugated PMOs (PPMOs) specific for the murine norovirus (MNV) genome was developed, and two PPMO compounds directed against the first AUG of the ORF1 coding sequence near the 5'-end of the genome proved effective in… CONTINUE READING