Inhibition of nitric oxide synthesis increases adenosine production via an extracellular pathway through activation of protein kinase C.

@article{Minamino1997InhibitionON,
  title={Inhibition of nitric oxide synthesis increases adenosine production via an extracellular pathway through activation of protein kinase C.},
  author={T. Minamino and M. Kitakaze and K. Node and H. Funaya and M. Hori},
  journal={Circulation},
  year={1997},
  volume={96 5},
  pages={
          1586-92
        }
}
BACKGROUND NO is known to deactivate protein kinase C (PKC). Because we have reported that the activation of PKC activates ecto-5'-nucleotidase, we examined whether the inhibition of NO synthesis increases ecto-5'-nucleotidase activity through the activation of PKC. METHODS AND RESULTS The left anterior descending coronary artery (LAD) was cannulated and perfused with blood through a bypass tube from the left carotid artery in 65 open-chest dogs. The intracoronary administration of NG-nitro-L… Expand
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