Inhibition of nitric oxide synthesis causes preterm delivery in the mouse.

@article{Tiboni2000InhibitionON,
  title={Inhibition of nitric oxide synthesis causes preterm delivery in the mouse.},
  author={Gian Mario Tiboni and Franca Giampietro},
  journal={Human reproduction},
  year={2000},
  volume={15 8},
  pages={1838-42}
}
The aim of the present study was to investigate whether an inhibitor of nitric oxide (NO) synthesis provokes preterm delivery in a mouse model. ICR (CD-1) mice were injected s.c. with N(G)-nitro-L-arginine methyl esther (L-NAME) at 0, 40, 70 or 100 mg/kg on gestation day (GD) 15.5 and 16. Delivery was considered preterm if it occurred before GD 18. In a satellite study, the potential ability of the NO donor sodium nitroprusside (SNP) to prevent L-NAME-induced preterm delivery was tested. Five… CONTINUE READING
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