Inhibition of nitric oxide synthesis blocks the inhibitory response to capsaicin in intestinal circular muscle preparations from different species.

  title={Inhibition of nitric oxide synthesis blocks the inhibitory response to capsaicin in intestinal circular muscle preparations from different species.},
  author={Rita Benkő and Zs{\'o}fia L{\'a}z{\'a}r and Sarolta Undi and L{\'a}szl{\'o} Ill{\'e}nyi and Andras Antal and {\~O}rs P{\'e}ter Horv{\'a}th and Zolt{\'a}n Rumbus and Matyas Wolf and Carlo A. Maggi and L{\'o}r{\'a}nd Barth{\'o}},
  journal={Life sciences},
  volume={76 24},

Functional study on TRPV1‐mediated signalling in the mouse small intestine: involvement of tachykinin receptors

  • J. D. De ManS. Boeckx P. Pelckmans
  • Biology, Chemistry
    Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society
  • 2008
Activation of TRPV1 in the mouse intestine induces a contraction that is mediated by tachykinins most likely released from afferent nerves, which does not involve activation of intrinsic enteric motor nerves.

Role of extrinsic afferent neurons in gastrointestinal motility.

It is proposed that NO may be a sensory neurotransmitter, which plays a role in sympathetic reflexes, such as the inhibition of GI motility after laparotomy or by peritoneal irritation in animals with functionally inhibited capsaicin-sensitive nerves.

Pulmonary , gastrointestinal and urogenital pharmacology Role of KATP channels and TRPV 1 receptors in hydrogen sulfide-enhanced gastric emptying of liquid in awake mice $ Jand

H2S donors-induced acceleration of gastric emptying and relaxation of pyloric sphincter muscle by KATP channel and TRPV1 receptor activations are suggested.

Localization of TRPV1 and contractile effect of capsaicin in mouse large intestine: high abundance and sensitivity in rectum and distal colon.

The present results suggest that TRPV1 channels located on the rectum and distal colon play a major role in the motor function in the large intestine.

The transient receptor potential vanilloid receptor 1, TRPV1 (VR1) inhibits peristalsis in the mouse jejunum.

  • R. Rahmati
  • Biology, Medicine
    Archives of Iranian medicine
  • 2012
The findings suggest that inhibition of contractions in mouse jejunum by TRPV1-receptor activation does involve a nitric oxide synthetase (NOS) pathway.


Results show that inhibition of nitric oxide synthesis blocks the inhibitory response to capsaicin in intestinal circular muscle preparations from different species and the basis of analgesic research.

Capsaicin-Induced Changes in LTP in the Lateral Amygdala Are Mediated by TRPV1

The results demonstrate that TRPV1 may be involved in the amygdala control of learning mechanisms and indicate that the appropriate choice of the anesthetics used is an important consideration when brain plasticity and the action of endovanilloids will be evaluated.



Nitric oxide is involved in the relaxant effect of capsaicin in the human sigmoid colon circular muscle

It is proposed that capsaicin causes the release of smooth muscle relaxant substance(s) from afferent nerve endings in the gut wall, in a tetrodotoxin-resistant manner.

Nitric oxide induces acetylcholine-mediated contractions in the guinea-pig small intestine

It is concluded that administration of exogenous NO in the guinea-pig ileum can lead to activation cholinergic and to a lesser degree tachykininergic neurones.

Involvement of endogenous tachykinins and CGRP in the motor responses produced by capsaicin in the guinea-pig common bile duct

In functional experiments, the effect exerted by neurotransmitters released from capsaicin-sensitive primary afferent nerve terminals in the isolated guinea-pig common bile duct was investigated and a complete reversal of the relaxant response to EFS into a contraction was obtained.