Inhibition of nitric oxide synthesis attenuates alcohol consumption in two strains of alcohol-preferring rats.

@article{Rezvani1995InhibitionON,
  title={Inhibition of nitric oxide synthesis attenuates alcohol consumption in two strains of alcohol-preferring rats.},
  author={Amir H. Rezvani and Devin Grady and Alberto Peek and Olgierd Pucilowski},
  journal={Pharmacology, biochemistry, and behavior},
  year={1995},
  volume={50 2},
  pages={265-70}
}
The effect of the nitric oxide synthase inhibitor NG-nitro-L-arginine methyl ester (L-NAME) on voluntary alcohol consumption was examined in two different strains of alcohol-preferring rats, in a continuous-access, two-bottle-choice paradigm. Compared with the vehicle, intraperitoneal injections of L-NAME significantly and dose-dependently (10, 30, and 60 mg/kg) suppressed alcohol intake and preference in both alcohol-preferring (P) and Fawn-Hooded (FH) rats. The effect of the highest dose of L… CONTINUE READING