Inhibition of nitric oxide synthase reduces motoneuron death due to spinal root avulsion.

@article{Wu1993InhibitionON,
  title={Inhibition of nitric oxide synthase reduces motoneuron death due to spinal root avulsion.},
  author={Wen Tung Wu and Lihua Li},
  journal={Neuroscience letters},
  year={1993},
  volume={153 2},
  pages={121-4}
}
Our previous studies have shown that nitric oxide synthase (NOS) can be induced in motoneurons after spinal root avulsion lesion and the lesion-induced NOS is coincident with the death of the injured neurons. The present study examined whether the death of injured motoneurons can be prevented by inhibition of NOS. Nitroarginine, a specific inhibitor of NOS, was injected into adult rats which underwent spinal root avulsion. At a dose of 50 mg/kg/day, nitroarginine significantly inhibited the… CONTINUE READING

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