Inhibition of nitric oxide synthase reduces motoneuron death due to spinal root avulsion.

  title={Inhibition of nitric oxide synthase reduces motoneuron death due to spinal root avulsion.},
  author={Wen Tung Wu and Lihua Li},
  journal={Neuroscience letters},
  volume={153 2},
Our previous studies have shown that nitric oxide synthase (NOS) can be induced in motoneurons after spinal root avulsion lesion and the lesion-induced NOS is coincident with the death of the injured neurons. The present study examined whether the death of injured motoneurons can be prevented by inhibition of NOS. Nitroarginine, a specific inhibitor of NOS, was injected into adult rats which underwent spinal root avulsion. At a dose of 50 mg/kg/day, nitroarginine significantly inhibited the… CONTINUE READING


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Publications referenced by this paper.
Showing 1-10 of 11 references

Possible involvement of nitric oxide in long - term potentiation

G. A.. Ben Bohmc, C., J. M. Stutzmann, A. Doble, J. C. Blanchard
Eur . J . Pharmacol . • 1992

NMDA receptor activalion induces nitric oxide synthcsis from arginine in rat brain slices

J. Garthwaite, G.. Palmer Garthwaite, J. R.M., S. Moncanada
Eur . J . Pharmacol . • 1991

Long-term depression.

Annual review of neuroscience • 1989

The absence of significanl postnatal motoneuron death in the brachial and lumbar spinal cord o 1 " the rat

R. ppenheim
J . Comp . Neurol . • 1986

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