Inhibition of nitric oxide synthase by 1-(2-trifluoromethylphenyl) imidazole (TRIM) in vitro: antinociceptive and cardiovascular effects.

@article{Handy1996InhibitionON,
  title={Inhibition of nitric oxide synthase by 1-(2-trifluoromethylphenyl) imidazole (TRIM) in vitro: antinociceptive and cardiovascular effects.},
  author={Rachel L. C. Handy and Hisham L. Harb and Patricia Te Arapo Wallace and Z A Gaffen and Kevin J. Whitehead and Philip Keith Moore},
  journal={British journal of pharmacology},
  year={1996},
  volume={119 2},
  pages={
          423-31
        }
}
1. The ability of a range of substituted imidazole compounds to inhibit mouse cerebellar neuronal nitric oxide synthase (nNOS), bovine aortic endothelial NOS (eNOS) and inducible NOS (iNOS) from lungs of endotoxin-pretreated rats was investigated. In each case the substrate (L-arginine) concentration employed was 120 nM. 2. 1-(2-Trifluoromethylphenyl) imidazole (TRIM) was a relatively potent inhibitor of nNOS and iNOS (IC50S of 28.2 microM and 27.0 microM respectively) but was a relatively weak… CONTINUE READING

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