Inhibition of nitric oxide production in RAW 264.7 cells by azaphilones from xylariaceous fungi.

  title={Inhibition of nitric oxide production in RAW 264.7 cells by azaphilones from xylariaceous fungi.},
  author={D. Quang and L. Harinantenaina and Takashi Nishizawa and T. Hashimoto and C. Kohchi and G. Soma and Y. Asakawa},
  journal={Biological & pharmaceutical bulletin},
  volume={29 1},
  • D. Quang, L. Harinantenaina, +4 authors Y. Asakawa
  • Published 2006
  • Chemistry, Medicine
  • Biological & pharmaceutical bulletin
  • The aim of this study was to discover a novel agent that suppresses nitric oxide (NO) production stimulated by lipopolysaccharide (LPS) in RAW 264.7 cells. We carried out a screening test in fifteen azaphilone compounds, which were isolated from xylariaceous inedible mushrooms. The structure-activity relationship was discussed; accordingly, azaphilones were divided into five groups based on the functional groups attached to the main azaphilone backbone. Rubiginosin A, an azaphilone with an… CONTINUE READING
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