Inhibition of nitric oxide generation and lipid peroxidation attenuates hemolysate-induced injury to cerebrovascular endothelium

@article{Kwan1997InhibitionON,
  title={Inhibition of nitric oxide generation and lipid peroxidation attenuates hemolysate-induced injury to cerebrovascular endothelium},
  author={Antonia Kwan and Nina J. Solenski and Neal F. Kassell and Kevin Sang Lee},
  journal={Acta Neurochirurgica},
  year={1997},
  volume={139},
  pages={240-248}
}
The mechanisms of hemolysate-induced cerebral injury following subarachnoid hemorrhage are just beginning to be clarified. This study examined the injurious effects of hemolysate on endothelial cells derived from bovine middle cerebral arteries, and evaluated the roles of lipid peroxidation and nitric oxide production in this type of damage. Cultured endothelial cells were grown to confluency on gelatin-coated plates. The cells were characterized as endothelial cells on the basis of morphology… CONTINUE READING