Inhibition of nicotinate phosphoribosyl transferase by nonsteroidal anti-inflammatory drugs: a possible mechanism of action.

@article{Gaut1971InhibitionON,
  title={Inhibition of nicotinate phosphoribosyl transferase by nonsteroidal anti-inflammatory drugs: a possible mechanism of action.},
  author={Zane N. Gaut and Harvey M. Solomon},
  journal={Journal of pharmaceutical sciences},
  year={1971},
  volume={60 12},
  pages={
          1887-8
        }
}
  • Zane N. Gaut, Harvey M. Solomon
  • Published 1971
  • Chemistry, Medicine
  • Journal of pharmaceutical sciences
  • When incubated with 14C-nicotinic acid and phosphorylribose-1-pyrophosphate, human platelet lysate incorporates radioactivity into nicotinic acid mononucleotide. Under these conditions, the apparent Km of nicotinic acid for nicotinate phosphoribosyl transferase is 2.4 × 10−5M. Along with 2-hydroxynicotinic acid (Ki = 2.3 × 10−4M), the following nonsteroidal anti-inflammatory compounds competed reversibly with nicotinic acid for the enzyme: flufenamic acid (Ki = 4.6 × 10−5M), mefenamic acid (Ki… CONTINUE READING