Inhibition of neutrophil oxidative burst and granule secretion by wortmannin: potential role of MAP kinase and renaturable kinases.

@article{SueAQuan1997InhibitionON,
  title={Inhibition of neutrophil oxidative burst and granule secretion by wortmannin: potential role of MAP kinase and renaturable kinases.},
  author={A K Sue-A-Quan and Lea Fialkow and Chris J. Vlahos and J A Schelm and Sergio Grinstein and Jeffrey R. Butler and Gregory P Downey},
  journal={Journal of cellular physiology},
  year={1997},
  volume={172 1},
  pages={94-108}
}
Exposure of neutrophils to a variety of agonists including soluble chemoattractant peptides and cytokines results in degranulation and activation of the oxidative burst (effector functions) that are required for bacterial killing. At present, the signaling pathways regulating these important functions are incompletely characterized. Mitogen-activated protein (MAP) kinases (MAPK) as well as members of a family of "renaturable kinases" are rapidly activated in neutrophils in response to diverse… CONTINUE READING
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