Inhibition of neutrophil migration by tumor necrosis factor. Ex vivo and in vivo studies in comparison with in vitro effect.

@article{Otsuka1990InhibitionON,
  title={Inhibition of neutrophil migration by tumor necrosis factor. Ex vivo and in vivo studies in comparison with in vitro effect.},
  author={Yasuo Otsuka and Kazuaki Nagano and Kazuyuki Hori and Jun-ichi Oh-ishi and Hisae Hayashi and Nobumoto Watanabe and Yoshiro Niitsu},
  journal={Journal of immunology},
  year={1990},
  volume={145 8},
  pages={
          2639-43
        }
}
Coincubation of neutrophils with TNF inhibited the chemoattractant-directed migration of neutrophils under agarose and enhanced their migration in the multiwell chemotaxis chamber. To assess the physiological significance of these differing in vitro TNF effects, ex vivo and in vivo investigations were performed using animal models. Neutrophils from the peripheral blood of rabbits preadministered systemic TNF showed impaired ability to migrate toward chemoattractants in vitro. In addition… CONTINUE READING

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