Inhibition of neutrophil apoptosis by acrolein: a mechanism of tobacco-related lung disease?

@article{Finkelstein2001InhibitionON,
  title={Inhibition of neutrophil apoptosis by acrolein: a mechanism of tobacco-related lung disease?},
  author={Erik I. Finkelstein and Mirella Nardini and Albert van der Vliet},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2001},
  volume={281 3},
  pages={
          L732-9
        }
}
Cigarette smoking is known to contribute to inflammatory diseases of the respiratory tract by promoting recruitment of inflammatory-immune cells such as neutrophils and perhaps by altering neutrophil functional properties. We investigated whether acrolein, a toxic unsaturated aldehyde found in cigarette smoke, could directly affect neutrophil function. Exposure of freshly isolated human neutrophils to acrolein markedly inhibited spontaneous neutrophil apoptosis as indicated by loss of membrane… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 55 REFERENCES

The molecular effects of acrolein.

  • Toxicological sciences : an official journal of the Society of Toxicology
  • 2000
VIEW 15 EXCERPTS
HIGHLY INFLUENTIAL

Glutathione depletion in lung cells by low-molecular-weight aldehydes

  • Cell Biology and Toxicology
  • 1999
VIEW 13 EXCERPTS
HIGHLY INFLUENTIAL

Comprehensive Toxicology: Respiratory Toxicology, edited by Sipes IG, McQueen CA, and Gandolfi AJ

Heck HDA Aldehydes
  • New York: Pergamon,
  • 1997
VIEW 13 EXCERPTS
HIGHLY INFLUENTIAL

Cigarette smoke induces interleukin-8 release from human bronchial epithelial cells.

  • American journal of respiratory and critical care medicine
  • 1997
VIEW 3 EXCERPTS
HIGHLY INFLUENTIAL

Apoptosis in resolution of inflammation.

  • Kidney & blood pressure research
  • 2000
VIEW 2 EXCERPTS