Inhibition of neurosteroid synthesis increases asphyxia-induced brain injury in the late gestation fetal sheep.

@article{Yawno2007InhibitionON,
  title={Inhibition of neurosteroid synthesis increases asphyxia-induced brain injury in the late gestation fetal sheep.},
  author={Tamara Yawno and Edwin Bingbing Yan and David W Walker and Jon J. Hirst},
  journal={Neuroscience},
  year={2007},
  volume={146 4},
  pages={1726-33}
}
Allopregnanolone (AP) is a potent GABAergic agonist that suppresses CNS activity, seizure threshold, and excitotoxicity in the adult brain. AP is present in the fetal sheep brain and increases rapidly after asphyxial insult due to increased 5alpha-reductase type-2 (5alphaR-2) expression. The aim of this study was to use finasteride to suppress fetal neurosteroid synthesis, and then determine the effect on brain injury, particularly in the hippocampus, of asphyxia induced in utero by brief… CONTINUE READING

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