Inhibition of neuropathic pain by selective ablation of brainstem medullary cells expressing the mu-opioid receptor.

@article{Porreca2001InhibitionON,
  title={Inhibition of neuropathic pain by selective ablation of brainstem medullary cells expressing the mu-opioid receptor.},
  author={F rank Porreca and Shannon E Burgess and Luis R. Gardell and Todd W. Vanderah and T. Philip Malan and Michael H. Ossipov and Douglas A. Lappi and Josephine Lai},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2001},
  volume={21 14},
  pages={5281-8}
}
Neurons in the rostroventromedial medulla (RVM) project to spinal loci where the neurons inhibit or facilitate pain transmission. Abnormal activity of facilitatory processes may thus represent a mechanism of chronic pain. This possibility and the phenotype of RVM cells that might underlie experimental neuropathic pain were investigated. Cells expressing mu-opioid receptors were targeted with a single microinjection of saporin conjugated to the mu-opioid agonist dermorphin; unconjugated saporin… CONTINUE READING
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disorders produced in rats by partial sciatic nerve injury

  • H Sun, K Ren, +4 authors F Porreca
  • 2001
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