Inhibition of neuroeffector transmission in human vas deferens by sildenafil.

  title={Inhibition of neuroeffector transmission in human vas deferens by sildenafil.},
  author={P. Sanchez de Medina and Gloria Segarra and Bel{\'e}n Torondel and Pascual Chuan and Cristina Dom{\`e}nech and Jos{\'e} M Vila and Salvador Lluch},
  journal={British journal of pharmacology},
  volume={131 5},
Sildenafil (0.1 - 30 microM), a cyclic GMP phosphodiesterase 5 (PDE 5) inhibitor, induced inhibition of electrically evoked contractions of ring segments of human vas deferens from 34 vasectomies. Zaprinast (0.1 - 100 microM), another PDE 5 inhibitor, and the nitric oxide (NO) donor sodium nitroprusside (SNP) (0.1 - 100 microM) had no effect on neurogenic contractions. The inhibition induced by sildenafil was not modified by the inhibitor of guanylate cyclase 1H-[1,2,4]oxadiazolo[4,3-a… CONTINUE READING


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