Inhibition of neointima formation after experimental coronary artery stenting: a new biodegradable stent coating releasing hirudin and the prostacyclin analogue iloprost.

@article{Alt2000InhibitionON,
  title={Inhibition of neointima formation after experimental coronary artery stenting: a new biodegradable stent coating releasing hirudin and the prostacyclin analogue iloprost.},
  author={Eckhard U. Alt and Iris H{\"a}hnel and C Beilharz and K Prietzel and D Preter and Andreas Stemberger and Theodor M. Fliedner and Wolf Erhardt and Albert Schoemig},
  journal={Circulation},
  year={2000},
  volume={101 12},
  pages={1453-8}
}
BACKGROUND To minimize acute stent thrombosis and development of restenosis, stents coated with biodegradable and nonbiodegradable polymers have been proposed to serve as sustained-release drug carriers. METHODS AND RESULTS In both a sheep and a pig model, we examined the vascular response to standard and high-pressure implantation of coronary Palmaz-Schatz stents coated with a 10-microm layer of polylactic acid (MW 30 kDa) releasing recombinant polyethylene glycol (r-PEG)-hirudin and the… CONTINUE READING