Inhibition of myosin ATPase by metal fluoride complexes.

  title={Inhibition of myosin ATPase by metal fluoride complexes.},
  author={Sungjo Park and Katalin Ajtai and Thomas P Burghardt},
  journal={Biochimica et biophysica acta},
  volume={1430 1},
Magnesium (Mg2+) is the physiological divalent cation stabilizing nucleotide or nucleotide analog in the active site of myosin subfragment 1 (S1). In the presence of fluoride, Mg2+ and MgADP form a complex that traps the active site of S1 and inhibits myosin ATPase. The ATPase inactivation rate of the magnesium trapped S1 is comparable but smaller than the other known gamma-phosphate analogs at 1.2 M-1 s-1 with 1 mM MgCl2. The observed molar ratio of Mg/S1 in this complex of 1.58 suggests that… CONTINUE READING


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