Inhibition of myofibroblast apoptosis by transforming growth factor beta(1).

@article{Zhang1999InhibitionOM,
  title={Inhibition of myofibroblast apoptosis by transforming growth factor beta(1).},
  author={Honglai Zhang and Sem H. Phan},
  journal={American journal of respiratory cell and molecular biology},
  year={1999},
  volume={21 6},
  pages={658-65}
}
Fibroblast differentiation to the myofibroblast phenotype is associated with alpha-smooth-muscle actin (alpha-SMA) expression and regulated by cytokines. Among these, transforming growth factor (TGF)-beta(1) and interleukin (IL)-1beta can stimulate and inhibit myofibroblast differentiation, respectively. IL-1beta inhibits alpha-SMA expression by inducing apoptosis selectively in myofibroblasts via induction of nitric oxide synthase (inducible nitric oxide synthase [iNOS]). Because TGF-beta is… CONTINUE READING