Inhibition of myeloid cell differentiation in cancer: the role of reactive oxygen species.

@article{Kusmartsev2003InhibitionOM,
  title={Inhibition of myeloid cell differentiation in cancer: the role of reactive oxygen species.},
  author={Sergei Kusmartsev and Dmitry I Gabrilovich},
  journal={Journal of leukocyte biology},
  year={2003},
  volume={74 2},
  pages={186-96}
}
It is well established that tumor growth is associated with accumulation of immature myeloid cells (ImC). They play an important role in tumor-associated immune suppression. ImC accumulate not only in tumor-bearing hosts but also in immunized, tumor-free hosts or hosts infected with bacterial pathogens. The kinetics of ImC in these mice is different. If in tumor-bearing mice, the number of ImC continues to increase with tumor progression in tumor-free mice after an initial spike, it decreases… CONTINUE READING
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