Inhibition of murine prostate tumor growth and activation of immunoregulatory cells with recombinant canarypox viruses.

@article{Griffith2001InhibitionOM,
  title={Inhibition of murine prostate tumor growth and activation of immunoregulatory cells with recombinant canarypox viruses.},
  author={Thomas S Griffith and Mutsushi Kawakita and Jun Tian and Julie K. Ritchey and James Tartaglia and Indu Sehgal and Timothy C Thompson and Weihong Zhao and Timothy L Ratliff},
  journal={Journal of the National Cancer Institute},
  year={2001},
  volume={93 13},
  pages={998-1007}
}
BACKGROUND Immunization with modified tumor cells carrying recombinant immunomodulatory genes is being explored as cancer immunotherapy. In this study, we examine whether canarypox ALVAC viruses carrying immunostimulatory cytokine genes (granulocyte-macrophage colony-stimulating factor, interleukin 2, interleukin 12, and tumor necrosis factor-alpha) can induce antitumor immunity (to rechallenge) in the RM-1 model of a highly aggressive, weakly immunogenic murine prostate cancer. METHODS For… CONTINUE READING