Inhibition of murine neutrophil serine proteinases by human and murine secretory leukocyte protease inhibitor.

@article{Wright1999InhibitionOM,
  title={Inhibition of murine neutrophil serine proteinases by human and murine secretory leukocyte protease inhibitor.},
  author={Clifford D. Wright and John A. Kennedy and R J Zitnik and Mohammed A Kashem},
  journal={Biochemical and biophysical research communications},
  year={1999},
  volume={254 3},
  pages={614-7}
}
Human secretory leukocyte protease inhibitor (SLPI) is a predominant physiologic inhibitor of elastase and cathepsin G, proinflammatory serine proteases released by activated neutrophils. In order to fully evaluate the potential pharmacologic efficacy of human SLPI in animal models of inflammation, it is critical to know the potency of the inhibitor for corresponding proteases from the species of interest. In this report, we compare the inhibitory activity of human and murine SLPI against… CONTINUE READING
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