Inhibition of multiple subtypes of influenza A virus in cell cultures with morpholino oligomers.

@article{Ge2006InhibitionOM,
  title={Inhibition of multiple subtypes of influenza A virus in cell cultures with morpholino oligomers.},
  author={Qing Ge and Manoj K Pastey and Darwyn Kobasa and Piliapan Puthavathana and Christopher R. Lupfer and Richard K. Bestwick and Patrick L. Iversen and Jianzhu Chen and David A. Stein},
  journal={Antimicrobial agents and chemotherapy},
  year={2006},
  volume={50 11},
  pages={3724-33}
}
Peptide-conjugated phosphorodiamidate morpholino oligomers (P-PMO) are single-stranded nucleic acid-like antisense agents that can reduce gene expression by sterically blocking complementary RNA sequence. P-PMO are water soluble and nuclease resistant, and they readily achieve uptake into cells in culture under standard conditions. Eight P-PMO, each 20 to 22 bases in length, were evaluated for their ability to inhibit influenza A virus (FLUAV) A/PR/8/34 (H1N1) replication in cell culture. The P… CONTINUE READING

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