Inhibition of multiple phases of human immunodeficiency virus type 1 replication by a dithiane compound that attacks the conserved zinc fingers of retroviral nucleocapsid proteins.

Abstract

The human immunodeficiency virus type 1 (HIV-1) nucleocapsid p7 protein contains two retrovirus-type zinc finger domains that are required for multiple phases of viral replication. Chelating residues (three Cys residues and one His residue) of the domains are absolutely conserved among all strains of HIV-1 and other retroviruses, and mutations in these… (More)

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Cite this paper

@article{Rice1997InhibitionOM, title={Inhibition of multiple phases of human immunodeficiency virus type 1 replication by a dithiane compound that attacks the conserved zinc fingers of retroviral nucleocapsid proteins.}, author={William G. Rice and David C. Baker and C{\'e}line Schaeffer and Luke Graham and Maoliang Bu and Sara J Terpening and Dana J Clanton and Ronald J. Schultz and John P. Bader and Robert W. Buckheit and Lorie Field and Pradhyuman K. Singh and Jim A. Turpin}, journal={Antimicrobial agents and chemotherapy}, year={1997}, volume={41 2}, pages={419-26} }