Inhibition of multidrug efflux as a strategy to prevent biofilm formation.

@article{Baugh2014InhibitionOM,
  title={Inhibition of multidrug efflux as a strategy to prevent biofilm formation.},
  author={Stephanie Baugh and Charlotte R Phillips and Aruna S Ekanayaka and Laura J. V. Piddock and Mark Alexander Webber},
  journal={The Journal of antimicrobial chemotherapy},
  year={2014},
  volume={69 3},
  pages={673-81}
}
OBJECTIVES We have recently shown that inactivation of any of the multidrug efflux systems of Salmonella results in loss of the ability to form a competent biofilm. The aim of this study was to determine the mechanism linking multidrug efflux and biofilm formation, and to determine whether inhibition of efflux is a viable antibiofilm strategy. METHODS Mutants lacking components of the AcrAB-TolC system in Salmonella enterica serovar Typhimurium were investigated for their ability to aggregate… CONTINUE READING