Inhibition of monocyte-derived inflammatory cytokines by IL-25 occurs via p38 Map kinase-dependent induction of Socs-3.

@article{Caruso2009InhibitionOM,
  title={Inhibition of monocyte-derived inflammatory cytokines by IL-25 occurs via p38 Map kinase-dependent induction of Socs-3.},
  author={Roberta Caruso and Carmine Stolfi and Massimiliano Sarra and Angelamaria Rizzo and Massimo Claudio Fantini and Francesco Pallone and Thomas Macdonald and Giovanni Monteleone},
  journal={Blood},
  year={2009},
  volume={113 15},
  pages={3512-9}
}
IL-25, a member of the IL-17 cytokine family, is known to enhance Th2-like responses associated with increased serum levels of IgE, IgG1, IgA, blood eosinophilia, and eosinophilic infiltrates in various tissues. However, IL-25 also abrogates inflammatory responses driven by Th17 cells. However, the cell types that respond to IL-25 and the mechanisms by which IL-25 differentially regulates immune reactions are not well explored. To identify potential targets of IL-25, we initially examined IL-25… CONTINUE READING

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