Inhibition of monocyte chemoattractant protein-1 by Krüppel-like factor 5 small interfering RNA in the tumor necrosis factor- alpha-activated human umbilical vein endothelial cells.

@article{Kumekawa2008InhibitionOM,
  title={Inhibition of monocyte chemoattractant protein-1 by Kr{\"u}ppel-like factor 5 small interfering RNA in the tumor necrosis factor- alpha-activated human umbilical vein endothelial cells.},
  author={Mari Kumekawa and Gen Fukuda and Saiko Shimizu and Kazushige Konno and Masato Odawara},
  journal={Biological & pharmaceutical bulletin},
  year={2008},
  volume={31 8},
  pages={1609-13}
}
Krüppel-like factor 5 (KLF5) is one of the pivotal transcriptional factors communicating with inflammatory cytokines. Regulation of monocyte chemoattractant protein-1 (MCP-1) is a target to prevent from inflammation and atherogenic changes in patient with diabetes mellitus. This study was made to determine whether KLF5 may associate with MCP-1 expression in human umbilical vein endothelial cells (HUVECs) induced by tumor necrosis factor-alpha (TNF-alpha), in terms of the initial events of… CONTINUE READING
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