Inhibition of monoamine oxidase in 5-hydroxytryptaminergic neurones by substituted p-aminophenylalkylamines.

@article{Ask1985InhibitionOM,
  title={Inhibition of monoamine oxidase in 5-hydroxytryptaminergic neurones by substituted p-aminophenylalkylamines.},
  author={A L Ask and Ingrid Fagervall and L G Florvall and Svante B. Ross and S Ytterborn},
  journal={British journal of pharmacology},
  year={1985},
  volume={85 3},
  pages={683-90}
}
A series of substituted p-aminophenethylamines and some related compounds were examined with regards to the inhibition of monoamine oxidase (MAO) in vivo inside and outside 5-hydroxytryptaminergic neurones in the rat hypothalamus. This was recorded as the protection against the irreversible inhibition of MAO produced by phenelzine by determining the remaining deaminating activity in the absence and presence of citalopram using a low (0.1 microM) concentration of [14C]-5-hydroxytryptamine (5-HT… CONTINUE READING