Inhibition of monoamine oxidase by two substrate-analogues, with different preferences for 5-hydroxytryptamine neurons

@article{Kim1991InhibitionOM,
  title={Inhibition of monoamine oxidase by two substrate-analogues, with different preferences for 5-hydroxytryptamine neurons},
  author={S. K. Kim and Y. Toyoshima and Y. Arai and H. Kinemuchi and K. Kisara},
  journal={Neuropharmacology},
  year={1991},
  volume={30},
  pages={329-335}
}
  • S. K. Kim, Y. Toyoshima, +2 authors K. Kisara
  • Published 1991
  • Chemistry, Medicine
  • Neuropharmacology
  • Various intraperitoneal doses of 5-fluoro-alpha-methyltryptamine (5-FMT), given to mice, dose-dependently inhibited only MAOA activity, with similar degrees of inhibition in the striatum, hypothalamus and the rest of the forebrain. The activity inhibited in these regions, completely recovered to control levels within 24 hr after the injection. In contrast, p-chloro-beta-methylphenethylamine (p-CMP), selectively inhibited MAOB activity, with complete recovery within 45 min after the injection… CONTINUE READING
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