Inhibition of monoamine oxidase by two substrate-analogues, with different preferences for 5-hydroxytryptamine neurons

@article{Kim1991InhibitionOM,
  title={Inhibition of monoamine oxidase by two substrate-analogues, with different preferences for 5-hydroxytryptamine neurons},
  author={S. K. Kim and Y. Toyoshima and Y. Arai and H. Kinemuchi and K. Kisara},
  journal={Neuropharmacology},
  year={1991},
  volume={30},
  pages={329-335}
}
  • S. K. Kim, Y. Toyoshima, +2 authors K. Kisara
  • Published 1991
  • Chemistry, Medicine
  • Neuropharmacology
    • Various intraperitoneal doses of 5-fluoro-alpha-methyltryptamine (5-FMT), given to mice, dose-dependently inhibited only MAOA activity, with similar degrees of inhibition in the striatum, hypothalamus and the rest of the forebrain. The activity inhibited in these regions, completely recovered to control levels within 24 hr after the injection. In contrast, p-chloro-beta-methylphenethylamine (p-CMP), selectively inhibited MAOB activity, with complete recovery within 45 min after the injection… CONTINUE READING
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    Alpha-methylated tryptamine derivatives induce a 5-HT receptor-mediated head-twitch response in mice
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    Synthesis of α- and β-methyl derivatives of 2-[(5-methoxy-1-methyl)indol-2-yl]ethylamine as selective inhibitors of monoamine oxidases A and B.
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    Multiscale simulation of monoamine oxidase catalyzed decomposition of phenylethylamine analogs
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    Why p-OMe- and p-Cl-β-Methylphenethylamines Display Distinct Activities upon MAO-B Binding
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    Effect of γ‐mangostin through the inhibition of 5‐hydroxytryptamine2A receptors in 5‐fluoro‐α‐methyltryptamine‐induced head‐twitch responses of mice
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    The Pivotal Neuroinflammatory, Therapeutic and Neuroprotective Role of Alpha-Mangostin
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    Why pOMe-and pCl-beta-Methylphenethylamines Display Distinct Activities uponMAO-B Binding
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    Medicinal Chemistry of Present and Future MAO-B Inhibitors
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    References

    SHOWING 1-10 OF 23 REFERENCES
    Potentiation of para-hydroxyamphetamine-induced head-twitch response by inhibition of monoamine oxidase type A in the brain.
    • 24
    Inhibition of monoamine oxidase by amphetamine and related compounds.
    • 166
    In vivo monoamine oxidase inhibition by d-amphetamine.
    • 117
    Studies of monoamine oxidase and semicarbazide-sensitive amine oxidase. II. Inhibition by alpha-methylated substrate-analogue monoamines, alpha-methyltryptamine, alpha-methylbenzylamine and two enantiomers of alpha-methylbenzylamine.
    • 15
    Studies on 5-fluoro-alpha-methyltryptamine and p-chloro-beta-methylphenethylamine: determination of the MAO-A or MAO-B selective inhibition in vitro.
    • 17
    Participation of brain monoamine oxidase B form in the neurotoxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine: Relationship between the enzyme inhibition and the neurotoxicity
    • 50
    Effect of an uptake inhibitor on serotonin metabolism in rat brain: studies with 3-(p-trifluoromethylphenoxy)-N-methyl-3-phenylpropylamine (Lilly 110140).
    • 199
    5-Hydroxytryptamine release in vivo from a cytoplasmic pool: studies on the 5-HT behavioural syndrome in reserpinized rats.
    • 71
    Interactions between reserpine and various compounds on the accumulation of [14C] 5-hydroxytryptamine and [3H]noradrenaline in homogenates from rat hypothalamus.
    • S. Ross
    • Chemistry, Medicine
    • Biochemical pharmacology
    • 1979
    • 26
    A new selective inhibitor for uptake of serotonin into synaptosomes of rat brain: 3-(p-trifluoromethylphenoxy). N-methyl-3-phenylpropylamine.
    • 358