Inhibition of monoamine oxidase by two substrate-analogues, with different preferences for 5-hydroxytryptamine neurons

@article{Kim1991InhibitionOM,
  title={Inhibition of monoamine oxidase by two substrate-analogues, with different preferences for 5-hydroxytryptamine neurons},
  author={S. K. Kim and Yoshie Toyoshima and Yuichiro Arai and Hiroyasu Kinemuchi and Takeshi Tadano and Katsuyuki Oyama and N. Satoh and Kensuke Kisara},
  journal={Neuropharmacology},
  year={1991},
  volume={30},
  pages={329-335}
}
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Alpha-methylated tryptamine derivatives induce a 5-HT receptor-mediated head-twitch response in mice
E(cid:128)ect of (cid:103) -mangostin through the inhibition of 5-hydroxy-tryptamine 2A receptors in 5-fluoro- (cid:97) -methyltryptamine-induced head-twitch responses of mice
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The results suggest that (cid:103) mangostin inhibits 5-FMT-induced head-twitch response in mice by blocking 5-HT 2A receptors not by blocking the release of 5- HT from the central neurone.
Synthesis of α- and β-methyl derivatives of 2-[(5-methoxy-1-methyl)indol-2-yl]ethylamine as selective inhibitors of monoamine oxidases A and B.
Multiscale simulation of monoamine oxidase catalyzed decomposition of phenylethylamine analogs
Why p-OMe- and p-Cl-β-Methylphenethylamines Display Distinct Activities upon MAO-B Binding
TLDR
Density Functional Theory quantum chemical calculations reveal that β-methylation and para-substitution underpin the observed activities sustained by calculated transition state energy barriers, attained conformations and key differences in their interactions in the substrate binding site.
Effect of γ‐mangostin through the inhibition of 5‐hydroxytryptamine2A receptors in 5‐fluoro‐α‐methyltryptamine‐induced head‐twitch responses of mice
TLDR
The results suggest that γ‐mangostin inhibits 5‐FMT‐induced head‐twitch response in mice by blocking 5‐HT2A receptors not by blocking the release of 5‐ HT from the central neurone.
The Pivotal Neuroinflammatory, Therapeutic and Neuroprotective Role of Alpha-Mangostin
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The pivotal role of α- MG in neuroinflammatory disorders is reviewed and it is confirmed that α-MG partakes in the major stages of tumor growth: initiation, promotion, and progression.
Why pOMe-and pCl-beta-Methylphenethylamines Display Distinct Activities uponMAO-B Binding
Despite their structural and chemical commonalities, p-chloro-β-methylphenethylamine and p-methoxy-β-methylphenethylamine display distinct inhibitory and substrate activities upon MAO-B binding.…
Revisiting Forbidden Drugs: Chemical and Pharmacological Perspectives Over Psychedelic Indoleamines and Entactogens as Promising Therapeutic Agents
Depression and anxiety disorders are a major challenge for modern psychiatry, especially when shown to be resistant to conventional means of treatment. Over the past decade, psychedelic and…
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References

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