Inhibition of monoamine oxidase by selected C5- and C6-substituted isatin analogues.

@article{ManleyKing2011InhibitionOM,
  title={Inhibition of monoamine oxidase by selected C5- and C6-substituted isatin analogues.},
  author={Clarina Ilara Manley-King and Jesper Van Den Bergh and Jacobus P Petzer},
  journal={Bioorganic & medicinal chemistry},
  year={2011},
  volume={19 1},
  pages={
          261-74
        }
}
Previous studies have shown that (E)-5-styrylisatin and (E)-6-styrylisatin are reversible inhibitors of human monoamine oxidase (MAO) A and B. Both homologues are reported to exhibit selective binding to the MAO-B isoform with (E)-5-styrylisatin being the most potent inhibitor. To further investigate these structure-activity relationships (SAR), in the present study, additional C5- and C6-substituted isatin analogues were synthesized and evaluated as inhibitors of recombinant human MAO-A and… CONTINUE READING
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