Inhibition of monoamine oxidase by C5-substituted phthalimide analogues.

@article{ManleyKing2011InhibitionOM,
  title={Inhibition of monoamine oxidase by C5-substituted phthalimide analogues.},
  author={Clarina Ilara Manley-King and Jacobus J. Bergh and Jacobus P Petzer},
  journal={Bioorganic & medicinal chemistry},
  year={2011},
  volume={19 16},
  pages={
          4829-40
        }
}
Literature reports that isatin as well as C5- and C6-substituted isatin analogues are reversible inhibitors of human monoamine oxidase (MAO) A and B. In general, C5- and C6-substitution of isatin leads to enhanced binding affinity to both MAO isozymes compared to isatin and in most instances result in selective binding to the MAO-B isoform. Crystallographic and modeling studies suggest that the isatin ring binds to the substrate cavities of MAO-A and -B and is stabilized by hydrogen bond… CONTINUE READING

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