Inhibition of monoamine oxidase activity by cannabinoids

  title={Inhibition of monoamine oxidase activity by cannabinoids},
  author={Zdeněk Fi{\vs}ar},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  • Z. Fišar
  • Published 18 April 2010
  • Biology, Chemistry, Medicine
  • Naunyn-Schmiedeberg's Archives of Pharmacology
Brain monoamines are involved in many of the same processes affected by neuropsychiatric disorders and psychotropic drugs, including cannabinoids. This study investigated in vitro effects of cannabinoids on the activity of monoamine oxidase (MAO), the enzyme responsible for metabolism of monoamine neurotransmitters and affecting brain development and function. The effects of the phytocannabinoid Δ9-tetrahydrocannabinol (THC), the endocannabinoid anandamide (N-arachidonoylethanolamide [AEA… 
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