Inhibition of monoamine oxidase activity after combined action of chlordimeform with the antidepressant nialamide

  title={Inhibition of monoamine oxidase activity after combined action of chlordimeform with the antidepressant nialamide},
  author={Fina P. Kaloyanova and A. Bainova and Z. K. Zaprianov},
  journal={Archives of Environmental Contamination and Toxicology},
The 40-day oral administration of 5, 10, and 50 mg/kg chlordimeform to male rats moderately decreased monoamine oxidase activity (MAO) in the brain, liver, and serum, determined with the substrates kynuramine, tyramine, tryptamine, serotonin, dopamine, and benzylamine. The enzyme was inhibited predominantly in the liver. The study of MAO inhibition after 10 days application of 2, 6, 10, 15, and 20 mg/kg nialamide revealed that 2 mg/kg had a threshold effect. A dose of 6 mg/kg resulted in a… Expand
3 Citations
Monoamine oxidase inhibition cannot account for changes in visual evoked potentials produced by chlordimeform
It is confirmed that chlordimeform is a MAO inhibitor at doses which produce behavioral and electrophysiological changes, but it is demonstrated further that the changes in visual evoked potentials produced by chlordimform are not a direct result of the inhibition of MAO. Expand
Chlordimeform produces profound, selective, and transient changes in visual evoked potentials of hooded rats
Acute exposure to CDM temporarily increased both the amplitude and latency of PREPs, but only the latency of FEPs; however, both PREP and FEP peak latencies were increased by CDM in dose-related fashions. Expand


The inhibition of A and B forms of MAO in the production of a characteristic behavioural syndrome in rats after l-tryptophan loading
It is concluded that the syndrome of hypermotility and tremor in rats pretreated with selective inhibitors of the A and B forms of MAO may be dependent on the formation of an N-substituted derivative of 5-HT which is at least partly deaminated by MAO-B. Expand
Studies on the functional role of intraneuronal monamine oxidase.
Rats treated with both diethyldithiocarbamate and nialamide exhibited a significantly greater increase in hypothalamic and heart dopamine than did rats treated with diethyllithiOCarbamate alone, indicating that MAO may also regulate endogenous NE synthesis and levels by limiting the intraneuronal availability of its precursor substance, dopamine. Expand
Inhibition of Monoamine Oxidase by the Pesticide Chlordimeform and Related Compounds
Examination of chlordimeform and related compounds as potential inhibitors of rat liver MAO in vitro found that symptoms manifested by rats poisoned by chlordIMEform and demethylchlordime form are similar to those elicited by sympathomimetic agents including known MAO inhibitors. Expand
A rapid spectrophotometric assay of mono-amine oxidase based on the rate of disappearance of kynuramine.
Intramolecular (nonenzymatic) condensation of the aminoaldehyde proved to be faster than the further oxidation of the aldehyde to the acid or lactam and has been developed into a rapid method for the assay of monoamine oxidase. Expand
Chlordimeform: Uncoupling activity against rat liver mitochondria☆
It is concluded that chlordimeform is an uncoupling agent with a potency and site of action close to but probably not identical to that of the classical uncoupler 2,4-dinitrophenol. Expand
Monoamine Oxidase Inhibitors, Tyramine, and Cheese
Marked potentiation of the pressor effects of tyramine hydrochloride, given orally and intravenously, was demonstrated in patients receiving a monoamine oxidase (MAO) inhibitor, and one of the hazards of treatment with MAO inhibitors is emphasized. Expand
Effects of chlorphenamidine and its metabolites on hela cells
The cytotoxicity of chlorphenamidine, its potential metabolites, and an analog, 5-chloro-2-nitrotoluene, was studied and the growth inhibition (ID50) based on inhibition of cell protein synthesis was determined, closely correlated with the comparative inhibitory activity of these compounds for RNA synthesis. Expand
Chlordimeform: a Pesticide Acting upon Amine Regulatory Mechanisms
ChLORDIMEFORM is a relatively new acaricide-insecticide of which the mode of action has not been elucidated, and belongs to a novel group of insecticides which possess a formamidine moiety. Expand
5-hydroxytryptamine content of banans and banana products.
  • G. Vettorazzi
  • Chemistry, Medicine
  • Food and cosmetics toxicology
  • 1974
The amount of 5-HT in the pulp of unprocessed bananas decreased during maturation, whereas that in the peel increased, and these findings are discussed in relation to the general problem of physiologically active amines present in food. Expand