Inhibition of monoamine oxidase activity after combined action of chlordimeform with the antidepressant nialamide

@article{Kaloyanova1981InhibitionOM,
  title={Inhibition of monoamine oxidase activity after combined action of chlordimeform with the antidepressant nialamide},
  author={Fina P. Kaloyanova and A. Bainova and Z. K. Zaprianov},
  journal={Archives of Environmental Contamination and Toxicology},
  year={1981},
  volume={10},
  pages={1-8}
}
The 40-day oral administration of 5, 10, and 50 mg/kg chlordimeform to male rats moderately decreased monoamine oxidase activity (MAO) in the brain, liver, and serum, determined with the substrates kynuramine, tyramine, tryptamine, serotonin, dopamine, and benzylamine. The enzyme was inhibited predominantly in the liver. The study of MAO inhibition after 10 days application of 2, 6, 10, 15, and 20 mg/kg nialamide revealed that 2 mg/kg had a threshold effect. A dose of 6 mg/kg resulted in a… Expand
3 Citations
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It is confirmed that chlordimeform is a MAO inhibitor at doses which produce behavioral and electrophysiological changes, but it is demonstrated further that the changes in visual evoked potentials produced by chlordimform are not a direct result of the inhibition of MAO. Expand
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