Inhibition of monoamine oxidase A promotes secretory differentiation in basal prostatic epithelial cells.

@article{Zhao2008InhibitionOM,
  title={Inhibition of monoamine oxidase A promotes secretory differentiation in basal prostatic epithelial cells.},
  author={Hongjuan Zhao and Rosalie Nolley and Zuxiong Chen and Stephen Reese and Donna M. Peehl},
  journal={Differentiation; research in biological diversity},
  year={2008},
  volume={76 7},
  pages={820-30}
}
Monoamine oxidase A (MAO-A) expression is associated with high-grade prostate cancer. Immunohistochemistry showed that MAO-A is also expressed in the basal epithelial cells of normal prostate glands. Using cultured primary prostatic epithelial cells as a model, we showed that MAO-A prevents basal epithelial cells from differentiating into secretory cells. Under differentiation-promoting conditions, clorgyline, an irreversible MAO-A inhibitor, induced secretory cell-like morphology and repressed… CONTINUE READING

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