Inhibition of mobilization of acetylcholine: the weak link in neuromuscular transmission during partial neuromuscular block with d-tubocurarine.

@article{Foldes1989InhibitionOM,
  title={Inhibition of mobilization of acetylcholine: the weak link in neuromuscular transmission during partial neuromuscular block with d-tubocurarine.},
  author={Francis F. Foldes and Ijaz A. Chaudhry and Minori Kinjo and Hideo Nagashima},
  journal={Anesthesiology},
  year={1989},
  volume={71 2},
  pages={218-23}
}
The authors have demonstrated earlier, by direct measurement of acetylcholine (ACh), that d-tubocurarine (d-Tc) and other nondepolarizing muscle relaxants decrease the release of ACh from the indirectly stimulated mouse hemidiaphragm preparation. It was the purpose of the present study to determine whether the decrease of the stimulated release of ACh and the increase in the intensity of the partial neuromuscular block observed at higher stimulation rates is caused by the inhibition of… CONTINUE READING