Inhibition of mitogen-activated protein/extracellular signal-regulated kinase improves endothelial function and attenuates Ang II-induced contractility of mesenteric resistance arteries from spontaneously hypertensive rats.

@article{Touyz2002InhibitionOM,
  title={Inhibition of mitogen-activated protein/extracellular signal-regulated kinase improves endothelial function and attenuates Ang II-induced contractility of mesenteric resistance arteries from spontaneously hypertensive rats.},
  author={Rhian M Touyz and Christian Deschepper and Jeong Bae Park and Gang He and Xin Chen and Mario Fritsch Neves and Agostino Virdis and Ernesto L Schiffrin},
  journal={Journal of hypertension},
  year={2002},
  volume={20 6},
  pages={
          1127-34
        }
}
OBJECTIVES Extracellular signal-regulated kinases (ERK1/2) modulate vascular smooth muscle cell (VSMC) growth and contractility, important factors in blood pressure regulation. In the present in vivo study, we investigated whether short-term inhibition of ERK1/2-dependent signaling pathways influences vascular function and blood pressure (BP) in spontaneously hypertensive rats (SHR). METHODS SHR and Wistar-Kyoto (WKY) rats were injected subcutaneously with either PD98059, selective MEK1/2… CONTINUE READING

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