Inhibition of mitogen-activated protein kinase kinase blocks proliferation of neural progenitor cells.

@article{Learish2000InhibitionOM,
  title={Inhibition of mitogen-activated protein kinase kinase blocks proliferation of neural progenitor cells.},
  author={Randall D. Learish and Matthew D. Bruss and Mary Haak-Frendscho},
  journal={Brain research. Developmental brain research},
  year={2000},
  volume={122 1},
  pages={
          97-109
        }
}
Nestin-expressing neural progenitor (NP) cells have been isolated from the subventricular zone (SVZ) of the brain and propagated with epidermal growth factor (EGF) and basic fibroblast growth factor (bFGF). In other neural cell types it has been shown that EGF and bFGF activate cell surface receptors involved in the mitogen-activated protein kinase (MAPK) signal pathway. To examine this issue in NP cells, we isolated primary SVZ cells and stimulated them with EGF and bFGF and then used a… CONTINUE READING

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