Inhibition of mitogen-activated protein kinase kinase does not impair primary activation of human platelets.

@article{BrschHaubold1996InhibitionOM,
  title={Inhibition of mitogen-activated protein kinase kinase does not impair primary activation of human platelets.},
  author={Angelika G. B{\"o}rsch-Haubold and Rita M Kramer and Stephanie Watson},
  journal={The Biochemical journal},
  year={1996},
  volume={318 ( Pt 1)},
  pages={
          207-12
        }
}
Mitogen-activated protein kinases (MAPKs), a family of protein serine/threonine kinases regulating cell growth and differentiation, are activated by a dual-specificity kinase through phosphorylation at threonine and tyrosine. We used a recently described selective inhibitor of the p42/p44mapk-activating enzyme, PD 98059 [2-(2'-amino-3'-methoxyphenyl)-oxanaphthalen-4-one], to investigate the role of the p42/p44mapk pathway in human platelets. PD 98059 inhibited p42/p44mapk activation in thrombin… CONTINUE READING

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