Inhibition of mitochondrial translation by calmodulin antagonist N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide.


The possible role of calmodulin in mitochondrial functions was investigated in Ehrlich ascites tumor cell and mouse liver mitochondria employing sulfonamide compounds as calmodulin indicators. N-[6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide (W7), the most potent of the sulfonamide compounds, inhibited mitochondrial protein synthesis and oxidative… (More)


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@article{Vijayasarathy1993InhibitionOM, title={Inhibition of mitochondrial translation by calmodulin antagonist N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide.}, author={Camasamudram Vijayasarathy and H. Raza and Narayan G Avadhani}, journal={Biochimica et biophysica acta}, year={1993}, volume={1143 1}, pages={38-44} }