Inhibition of mitochondrial respiration by furancarboxylic acid accumulated in uremic serum in its albumin-bound and non-dialyzable form.

@article{Niwa1993InhibitionOM,
  title={Inhibition of mitochondrial respiration by furancarboxylic acid accumulated in uremic serum in its albumin-bound and non-dialyzable form.},
  author={Toshimitsu Niwa and Toshihiro Aiuchi and Ken-ichi Nakaya and Yuko Emoto and Teruo Miyazaki and K. I. Maeda},
  journal={Clinical nephrology},
  year={1993},
  volume={39 2},
  pages={92-6}
}
3-carboxy-4-methyl-5-propyl-2-furanpropionic acid (CMPF) accumulates markedly in uremic serum in its albumin-bound form. To determine if CMPF can be removed by newly developed dialyzers with high-flux membranes which are permeable to low-molecular-weight proteins, such as beta 2-microglobulin (beta 2-MG), serum levels of CMPF were determined before and after hemodialysis using these high-flux membrane dialyzers. In addition, to determine the pathogenic role of CMPF in uremic patients, its… CONTINUE READING

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Uremic toxicity: present state of the art.

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