Inhibition of mitochondrial protein synthesis impaired C2C12 myoblast differentiation.

  title={Inhibition of mitochondrial protein synthesis impaired C2C12 myoblast differentiation.},
  author={N Hamai and Masataka Nakamura and Atsushi Asano},
  journal={Cell structure and function},
  volume={22 4},
Various factors are required for the regulation of muscle cell differentiation. In an attempt to elucidate the mechanism underlying myogenesis, we examined the possible contribution of mitochondria to terminal differentiation of murine myoblast cell line, C2C12, using a specific inhibitor for mitochondrial protein synthesis, tetracycline. Tetracycline impaired myotube formation and induction of muscle creatine kinase activity which was specifically observed in differentiated myocytes… CONTINUE READING


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