Inhibition of mitochondrial glycerol-3-phosphate dehydrogenase by α-tocopheryl succinate.

Abstract

α-Tocopheryl succinate (TOS), a redox-silent analogue of vitamin E, suppresses cell growth in a number of clinical and experimental cancers, inhibits mitochondrial succinate dehydrogenase (SDH) and activates reactive oxygen species (ROS) generation. The aim of this study was to test whether TOS also inhibits glycerol-3-phosphate dehydrogenase (mGPDH… (More)
DOI: 10.1016/j.biocel.2014.06.010

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