Inhibition of mitochondrial function by efavirenz increases lipid content in hepatic cells.

@article{BlasGarcia2010InhibitionOM,
  title={Inhibition of mitochondrial function by efavirenz increases lipid content in hepatic cells.},
  author={Ana Blas-Garcia and Nadezda Apostolova and Daniel Ballesteros and Daniel Monleon and Jos{\'e} Manuel Morales and Milagros Rocha and Victor M Victor and Juan V Esplugues},
  journal={Hepatology},
  year={2010},
  volume={52 1},
  pages={
          115-25
        }
}
UNLABELLED Efavirenz (EFV) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) widely used in human immunodeficiency virus (HIV) infection therapy. It has been associated with hepatotoxic effects and alterations in lipid and body fat composition. Given the importance of the liver in lipid regulation, we have evaluated the effects of clinically used concentrations of EFV on the mitochondria and lipid metabolism of human hepatic cells in vitro. Mitochondrial function was rapidly… CONTINUE READING
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